TRANSLATIONAL PHYSIOLOGY A novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac arrest
نویسندگان
چکیده
Jing Li, Huashan Wang, Qiang Zhong, Xiangdong Zhu, Sy-Jou Chen, Yuanyu Qian, Jim Costakis, Gabrielle Bunney, David G. Beiser, Alan R. Leff, E. Douglas Lewandowski, J. Michael O Donnell, and Terry L. Vanden Hoek Program in Advanced Resuscitation Medicine, Center for Cardiovascular Research, and Department of Emergency Medicine, University of Illinois Hospital & Health Sciences System, Chicago, Illinois; Department of Emergency Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, China; Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan; Emergency Department, Chinese PLA General Hospital, Beijing, China; Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, Illinois; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois; and Program in Integrative Cardiac Metabolism, Center for Cardiovascular Research, and Department of Physiology and Biophysics, University of Illinois Hospital & Health Sciences System, Chicago, Illinois
منابع مشابه
A novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac arrest.
Sudden cardiac arrest (SCA) is a leading cause of death in the United States. Despite return of spontaneous circulation, patients die due to post-SCA syndrome that includes myocardial dysfunction, brain injury, impaired metabolism, and inflammation. No medications improve SCA survival. Our prior work suggests that optimal Akt activation is critical for cooling protection and SCA recovery. Here,...
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